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All of these factors can make it difficult to compare the results of one study with those of another.Table 1 briefly summarizes the findings discussed in more detail in this fact sheet on the safety and efficacy of the most common ingredients of weight-loss dietary supplements.For more information about dietary supplement regulation, see the Office of Dietary Supplements (ODS) publication, Dietary Supplements: What You Need to Know.Weight-loss dietary supplements contain a wide variety of ingredients.**The evidence of efficacy and safety is for the individual ingredients.

Some safety concerns reported, especially for combinations with other stimulants Reported adverse effects: Chest pain, anxiety, headache, musculoskeletal complaints, and increased blood pressure and heart rate Safety concerns not usually reported at intakes less than 400–500 mg/day for adults, significant safety concerns at higher doses Reported adverse effects: Nervousness, jitteriness, vomiting, and tachycardia No safety concerns reported at recommended intakes (1,000–1,200 mg/day for adults) Reported adverse effects: Constipation, kidney stones, and interference with zinc and iron absorption at intakes above 2,000–2,500 mg for adults Few safety concerns reported for up to 33 mg/day for 4 weeks or 4 mg/day for 12 weeks Reported adverse effects: Gastrointestinal distress, increased insulin levels, and decreased high-density lipoprotein (HDL) levels No safety concerns reported for up to 2 g/day for 1 year or 4 g/day for 56 days Reported adverse effects: Nausea, vomiting, diarrhea, abdominal cramps, and a “fishy” body odor; might increase trimethylamine N-oxide (TMAO) levels, which are linked to greater cardiovascular disease risk No safety concerns reported for recommended intakes (20–45 mcg/day for adults) Reported adverse effects: Headache, watery stools, constipation, weakness, vertigo, nausea, vomiting, and urticaria (hives)Few safety concerns reported for 2.4–6 g/day for up to 12 months Reported adverse effects: Abdominal discomfort and pain, constipation, diarrhea, loose stools, dyspepsia, and (possibly) adverse effects on blood lipids and glucose homeostasis Significant safety concerns reported for tablet forms, which might cause esophageal obstructions, but few safety concerns with up to 15.1 g/day of other forms for several weeks Reported adverse effects: Loose stools, flatulence, diarrhea, constipation, and abdominal discomfort No safety concerns reported for use as a beverage, contains caffeine; some safety concerns reported for green tea extract Reported adverse effects (for green tea extract): Constipation, abdominal discomfort, nausea, increased blood pressure, and liver damage No safety concerns reported at recommended intakes (600–800 IU/day for adults); toxic at very high intakes; tolerable upper intake level of 4,000 IU/day for adults Reported adverse effects: Anorexia, weight loss, polyuria, heart arrhythmias, and increased calcium levels leading to vascular and tissue calcification * References to support statements in Table 1 are provided in subsequent text.Complicating the interpretation of many study results is the fact that most weight-loss dietary supplements contain multiple ingredients, making it difficult to isolate the effects of each ingredient and predict the effects of the combination.Evidence may exist for just one of the ingredients in a finished product, and no evidence may be available for an ingredient when it is combined with other ingredients.The FDA and the Federal Trade Commission can also take regulatory actions against manufacturers that make unsubstantiated weight-loss claims about their products.The FDA does not permit dietary supplements to contain pharmaceutical ingredients, and manufacturers may not promote dietary supplements to diagnose, treat, cure, or prevent any disease [13].

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